colored TEM of a blood vessel in cross section
stack of erythrocytes, plus one crawling lymphocyte, can be seen, in addition to some mitochondria and rough ER in the surrounding vascular endothelium
credit: University of Edinburgh
rouleaux formation of erythrocytes
from the French, rolel, the diminutive of role, meaning “roll” (which, to note, is derived from the Latin, rotula, meaning “little wheel”)
this abnormal stacking formation occurs in response to increased plasma proteins (globulins, fibrinogen) during inflammation
credit: Thomas Deerinck
Cerebral Purkinje Neurons
Cerebral Purkinje cells have been researched for decades along side the cerebral supporting cast of granular cells and interneurons. Purkinje cells are known for their abundance of very active dendrites that can create action potentials and are also capable of receiving input from over 200,000 other cells.
Purkinje cells are huge by neuronal standards with diameters almost as large as a human hair. For scale, a Purkinje neuron is ten times as big as the smallest cerebellar neuron, the granular cell, yet there as almost as many of the tiny granular cells in the cerebellum as there are all the neurons in the rest of the central nervous system.
Purkinje neurons are the lone source of output from the cerebellum’s cortex. These neurons are unusually inhibitory, selectively suppressing excitatory impulses from other cells and crafting them into a coherent message that the rest of the brain can easily understand. While the general shape of the Purkinje neuron and its connections are fairly well known, the way it operates on a systems or network level is still largely unknown.
I can’t really explain why, but abandoned places like this have always fascinated me. Maybe it’s the stories they can tell. So much more interesting than the cut and paste type of architecture that has become the norm today….
SEM image of E. Coli bacteria and macrophages
MSF is deeply concerned by the British Prime Minister’s statement yesterday, proposing to use more DFID funding to stabilise conflict-affected states to further national security interests. Aid must not be hijacked as a political tool, Mr Cameron.
Image by Fernan Federici, PJ Steiner, Tim Rudge, and Jim Haseloff, University of Cambridge.
bacteria, always taking my breath.
Immunostaining for IgA in a patient with Henoch-Schönlein nephritis.
Liberian project coordinator Toe Jackson describes how his MSF team brought much-needed medical care to conflict-ridden Timbuktu, Mali.